Pharma Appraisal
November, 21 2025
Insurance Formulary Tiers Explained: Tier 1, Tier 2, Tier 3, and Non-Formulary Drugs

Ever filled a prescription and been shocked by the price-even though your insurance was supposed to cover it? That’s not a mistake. It’s likely because your drug landed in a higher tier than you expected. Insurance formulary tiers are the hidden system that decides how much you pay for your meds. Understanding them isn’t just helpful-it can save you hundreds, even thousands, a year.

What Is a Formulary, Anyway?

A formulary is simply a list of prescription drugs your insurance plan covers. It’s not random. Every drug on that list is sorted into tiers based on cost, effectiveness, and how much the insurer can negotiate with drugmakers. Think of it like a grocery store’s pricing: store-brand cereal is cheaper than the fancy name brand. Same idea-with drugs.

Most plans use three to five tiers. Some even have a sixth for the most expensive specialty drugs. But the core structure stays the same: lower tiers = lower out-of-pocket costs. Higher tiers = you pay more.

Tier 1: The Cheapest Option-Usually Generics

Tier 1 is where you want to be. This tier is mostly filled with generic drugs-medications that have the same active ingredients as brand-name versions but cost far less because the patent has expired.

For most commercial plans, a 30-day supply of a Tier 1 drug costs between $0 and $15. Medicare Part D plans often charge $0 or $5 for Tier 1 generics. That’s it. No coinsurance. No deductible. Just a flat copay.

Common Tier 1 drugs include:

  • Metformin (for diabetes)
  • Atorvastatin (for high cholesterol)
  • Levothyroxine (for hypothyroidism)
  • Lisinopril (for high blood pressure)
These are the backbone of chronic disease management. Insurers love them because they’re effective, safe, and cheap. And if your doctor prescribes one of these, you’re getting the best deal your plan offers.

Tier 2: Preferred Brand-Name Drugs

Tier 2 is where brand-name drugs live-if they’ve been negotiated into the “preferred” category. These aren’t generics, but your insurer has struck a deal with the manufacturer to lower the price. Maybe they got a big rebate. Maybe there’s another similar drug on Tier 3, and they want to steer you toward this one.

Copays here typically range from $20 to $40 for a 30-day supply. It’s more than Tier 1, but still manageable. You’re paying more than a generic, but less than you would if this drug were on Tier 3.

Examples of Tier 2 drugs:

  • Losartan (brand: Cozaar)
  • Simvastatin (brand: Zocor)
  • Glimepiride (brand: Amaryl)
The key thing to remember: just because a drug is brand-name doesn’t mean it’s automatically Tier 2. Some brand-name drugs are on Tier 3 or even higher. It all depends on what your insurer negotiated.

Tier 3: Non-Preferred Brand-Name Drugs

This is where things get expensive. Tier 3 drugs are brand-name medications with no preferred status. Maybe there’s a cheaper alternative on Tier 2. Maybe the manufacturer didn’t offer a good rebate. Or maybe the drug is newer and hasn’t been evaluated yet.

Copays here? Usually $50 to $100 for a 30-day supply. Some plans even use coinsurance-meaning you pay a percentage (like 30%) of the drug’s total cost. That can mean $150 or more if the drug costs $500.

Common Tier 3 drugs:

  • Brand-name insulin (like Humalog or NovoLog)
  • Brand-name asthma inhalers (like Advair or Symbicort)
  • Some antidepressants and antipsychotics
This tier is a big reason why people skip doses or stop taking meds altogether. A 2022 Patient Advocate Foundation survey found that 41% of patients delayed filling prescriptions because of high Tier 3 or higher costs.

A corporate PBM mech manipulating drug tiers with digital strings, a patient's hologram pleading for help.

Tier 4 and 5: Specialty Drugs-The High-Cost Zone

Not all plans have these, but more than 78% of employer-sponsored plans now do. Tier 4 and 5 are reserved for specialty drugs-usually those used for complex, chronic, or rare conditions like cancer, rheumatoid arthritis, multiple sclerosis, or hepatitis C.

These aren’t simple pills. They’re often injectables, infusions, or highly complex formulations. They can cost thousands per month.

Instead of a flat copay, you usually pay coinsurance: 25% to 50% of the drug’s total cost. So if your drug costs $8,000 a month, you could owe $2,000 to $4,000-even with insurance.

Examples:

  • Humira (for autoimmune diseases)
  • Keytruda (for cancer)
  • Spinraza (for spinal muscular atrophy)
Medicare Part D has a separate “specialty tier” that works similarly. But starting in 2024, the Inflation Reduction Act capped insulin at $35 per month regardless of tier. That’s a rare win for patients.

Non-Formulary: The “Not Covered” Zone

This isn’t a tier. It’s the black hole.

Drugs on the non-formulary list aren’t covered at all. Your plan won’t pay anything. You’re on the hook for 100% of the cost.

Why would a drug be excluded? Maybe it’s too new. Maybe there’s a cheaper, equally effective alternative. Maybe the manufacturer refused to negotiate. Or maybe the drug is off-label for your condition.

Common non-formulary drugs include:

  • Brand-name drugs with generic equivalents already on Tier 1
  • Drugs with serious safety concerns
  • Medications for conditions not covered under your plan’s scope
If your doctor prescribes a non-formulary drug, you have two options: pay full price, or ask for a formulary exception.

How Do Drugs Get Assigned to a Tier?

It’s not magic. It’s business.

Pharmacy Benefit Managers (PBMs)-like CVS Caremark, Express Scripts, and OptumRx-manage 85% of formularies. They negotiate with drugmakers. They look at:

  • Cost of the drug
  • Availability of cheaper alternatives
  • Rebates offered by the manufacturer
  • Clinical effectiveness
  • How often it’s prescribed
A drug can move tiers at any time. Plans can update their formularies quarterly. That means a drug you’ve been taking for years could suddenly jump from Tier 2 to Tier 3-or get kicked off the list entirely-with little or no warning.

A 2022 Kaiser Family Foundation study found that 43% of commercial plan members had at least one medication moved to a higher tier in the past year. No notice. No explanation. Just a higher bill.

A pharmacist handing a pill to a patient as a drug shifts to non-formulary on a glowing screen.

What Can You Do If Your Drug Is in a High Tier?

You’re not powerless.

1. Ask your doctor for alternatives. Is there a Tier 1 or Tier 2 drug that works just as well? Many chronic conditions have multiple treatment options.

2. Request a formulary exception. If your doctor says the higher-tier drug is medically necessary, they can submit a request. You’ll need a letter of medical necessity. This isn’t a guarantee-but it works. The Medicare Rights Center reports that 60% of exception requests for Tier 3 drugs are approved.

3. Use a patient assistance program. Many drugmakers offer discounts or free drugs to people who qualify based on income. Check the manufacturer’s website.

4. Shop around. Use tools like GoodRx, SingleCare, or your plan’s drug cost finder. Sometimes paying cash is cheaper than using insurance, especially for Tier 3 drugs.

How to Avoid Surprises

The biggest problem? People don’t check until it’s too late.

Here’s how to stay ahead:

  • Review your plan’s Summary of Benefits and Coverage (SBC) every year during open enrollment.
  • Download your plan’s full formulary list-it’s usually 100+ pages, but search for your meds.
  • Use your insurer’s online drug cost tool. Enter your drug, dose, and pharmacy.
  • Ask your pharmacist: “What tier is this on my plan?” before you pay.
  • Keep a list of your meds and their tiers. Update it every time you get a new prescription.

Why This System Exists-and Why It’s Flawed

Tiered formularies were designed to save money. And they have. Since the 1990s, they’ve reduced overall drug spending by 18-22%, according to experts.

But they’ve also created confusion. A 2022 Harvard study found that 61% of patients couldn’t accurately predict their out-of-pocket cost before filling a prescription.

And they hurt people who need the most expensive drugs. A 2021 JAMA study showed that each additional tier increases the chance someone will stop taking their meds by 5.7%.

The system works great for generics and common chronic conditions. But for rare diseases, cancer treatments, or patients with low incomes? It often fails.

Final Thought: Know Your Plan, Know Your Meds

Insurance formulary tiers aren’t going away. They’re the standard. But you don’t have to be a victim of them.

Take 20 minutes this week to look up your top three prescriptions. Find their tiers. Talk to your doctor. Ask about alternatives. Use a cost-checking tool. You might find a way to cut your monthly drug bill in half.

It’s not about fighting the system. It’s about navigating it-before the bill arrives.

What does it mean if a drug is non-formulary?

A non-formulary drug is not covered by your insurance plan at all. You’ll pay 100% of the cost out of pocket. This usually happens when there’s a cheaper, equally effective alternative on the formulary, or the drug is too new, too expensive, or not approved for your condition. You can sometimes get it covered by requesting a formulary exception with a letter from your doctor.

Can a drug move from Tier 1 to Tier 3 during the year?

Yes. Insurance plans can change their formularies up to four times a year-quarterly. A drug you’ve been taking for years could suddenly be moved to a higher tier or even removed entirely. You might not get advance notice. Always check your formulary before refilling prescriptions, especially during open enrollment or if you get a new bill.

Is a generic drug always in Tier 1?

Mostly, yes. But not always. Some plans have multiple generic tiers. For example, a generic version of a brand-name drug might be on Tier 2 if a different generic (from another manufacturer) is preferred. Or if the generic is newly approved and hasn’t been fully evaluated, it might be placed in Tier 2 temporarily. Always verify the tier for your specific generic.

Why are some brand-name drugs cheaper than generics?

It’s rare, but it happens. Sometimes a manufacturer offers a huge rebate to the insurer, making the brand-name drug cheaper than the generic. Other times, the generic is priced high because it’s from a small manufacturer with little competition. Always compare prices using tools like GoodRx-even if a drug is branded, it might cost less than the generic version.

How do I find out what tier my drug is on?

Log into your insurance plan’s website and use their drug formulary search tool. You can also call the customer service number on your card and ask for the tier of your specific medication. Most plans also send a printed formulary booklet during open enrollment. If you can’t find it, request a copy-by law, they must provide it.

Does Medicare have the same tiers as private insurance?

Medicare Part D uses a similar four-tier system: Tier 1 (lowest copay for generics), Tier 2 (preferred brands), Tier 3 (non-preferred brands), and a Specialty tier for high-cost drugs. But Medicare has stricter rules: all plans must cover at least two drugs per therapeutic class, and they must have an exception process. Also, insulin is capped at $35/month regardless of tier. Private plans have more flexibility-and often more complexity.

Tags: insurance formulary tiers Tier 1 drugs Tier 2 drugs Tier 3 drugs non-formulary drugs
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